新型高效杀虫剂茚虫威毒理学研究进展_王建军(2)

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ininsecticide-resistantSpodopterafrugiperda(Lepidoptera:Noctuidae)andPlutellaxylostella(Lepidoptera:Yponomeu-[J],63:,表明茚虫威抗性基因与以前发现的杀虫剂抗性

基因有所不同。增效试验表明,家蝇对茚虫威的抗性可以部分被多功能氧化酶抑制剂氧化胡椒基丁醚(PBO)克服,但增效剂DEF和顺丁烯二酸二乙酯(DEM)对抗性没有影响,表明有可能是多功能氧化酶,而不是酯酶或谷胱苷肽S-转移酶与家蝇对茚虫威的抗性相关

[16]

。然而对茚虫威抗性小菜蛾的增效试验却发

[17]

现,小菜蛾对茚虫威的抗性与酯酶相关,表明不同昆

虫对茚虫威的抗性机制可能存在差异。

4　结语

以钠离子通道为靶标的新型高效杀虫剂茚虫威,具有卓越的杀虫活性和独特的作用机制,商业化将使之在未来害虫化学防治中发挥重要的作用。但从目前国内外关于茚虫威毒理学的研究现状来看,有关环境因子对茚虫威生物活性的影响还研究甚少,茚虫威对昆虫钠离子通道的结合位点仍不明确,对于茚虫威的代谢抗性机制研究还只局限于家蝇和小菜蛾两种昆虫,靶标抗性机制研究更是未见报道。今后有必要对这些问题进一步进行研究,从而为科学、合理使用茚虫威、深入了解昆虫钠离子通道结构和功能的关系以及制定茚虫威抗性治理策略、延长其使用寿命提供理论依据。

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